Protective effect of rutin and ellagic acid on isoproterenol-induced myocardial infarction in wistar rats

The present study investigated the protective effect of rutin and ellagic acid (EA) alone and in combination on serum and heart tissue lipids and membrane bound enzymes on isoproterenol (ISO)induced myocardial infarction (MI) in rats. Rats induced with ISO (85 mg/ kg) showed a significant increase in the level of total cholesterol (TC), triglyceride (TG) and free fatty acid (FFA) in serum and heart and altered levels of lipoproteins in serum were observed. Phospholipids (PL) level were increased in serum and decreased in heart in ISO-induced rats. Altered activities of membrane bound enzymes and the levels of glucose, uric acid and protein were observed in ISO-induced rat heart. Pretreatment with rutin (10 mg/kg) and EA (30 mg/kg) alone and in combination for a period of 14 days exhibited a significant protective effect on lipids, lipoproteins, membrane bound enzymes and other biochemical parameters in ISOinduced rats. Thus our findings indicate that rutin and EA have cardioprotective effect in ISO-induced MI in rats. Also found that combined treatment possesses more protection than individual treatment.